Posted 1/2/2024, 3:53:37 PM
New SPACEL toolkit uses AI to map cell locations and rebuild 3D tissue structures from spatial transcriptomics data
- SPACEL is a new toolkit for analyzing spatial transcriptomics data across multiple tissue slices to build 3D tissue structures
- It has 3 modules Spoint for cell type prediction, Splane for identifying spatial domains, and Scube for 3D tissue reconstruction
- Spoint uses a neural network and probability model to predict cell type distributions
- Splane employs graph neural networks and adversarial learning to identify spatial domains across slices
- Scube aligns slices and stacks them to construct a 3D tissue architecture using graph and evolutionary algorithms