Baldur's Gate 3: The Choice Between Gortash and Orin Will Lock Certain Quests and Change Companion Approval
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Gortash is a main antagonist in Baldur's Gate 3 who offers you a deal to kill Orin and control the Elderbrain.
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Accepting Gortash's deal makes the game easier but loses Karlach's approval and locks some side quests.
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Refusing Gortash's deal means fighting him later but keeping side quests and Karlach's approval.
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Orin also offers a deal to kill Gortash then fight her, doesn't have Gortash's pull but captures a party member.
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Siding with Orin over Gortash may be better to protect your captured party member.