Posted 2/15/2024, 10:14:04 AM
New Machine Learning Framework Predicts Protein Interactions, Enables Viral Discovery
- Developed Tapioca, a machine learning framework to predict protein-protein interaction networks
- Tapioca enabled study of host regulation during reactivation of an oncogenic virus
- Introduced interactome homology analysis to identify a proviral host factor relevant for herpesviruses
- Framework integrates thermal proteome profiling, protein complex isolation, and machine learning
- Enables systems-level study of protein interaction dynamics and biological discovery