AI Helps Reveal How Flexible Cell Division Proteins Interact

For most proteins, structure determines function, but some proteins are intrinsically disordered with flexible structures.
Scientists have found that some intrinsically disordered proteins can adopt a structure when interacting with other proteins.
Google's AlphaFold AI was able to predict the structure of two interacting, intrinsically disordered proteins involved in cell division.
Researchers wanted to understand how the disordered proteins protein 4.1G and NuMA interact during cell division.
Figuring out the structures of interacting, disordered proteins has been a challenge that AlphaFold helped address for these cell division proteins.

arstechnica.com

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Posted 9/19/2023, 6:06:42 PM