Posted 1/29/2024, 3:22:03 PM
Computational Methods Reveal New Conformation of Kidney Transporter Protein, Offering Clues to Prevent Kidney Stones
- Researchers unveil previously unknown conformational state of OxlT transporter protein using advanced computational methods
- OxlT plays vital role in preventing kidney stones; understanding its structure key to managing oxalate levels
- Study utilizes Gaussian accelerated molecular dynamics and AlphaFold2 to successfully predict OxlT's inward-open state
- Inward-open structure shows OxlT prefers binding to formate over oxalate
- Research methodology provides template for exploring dynamics of other transporter proteins, targets for drugs