New method predicts drug interactions in the gut
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Researchers developed a new method to identify which transporter proteins help drugs pass through the digestive tract. This can predict if drugs interfere with each other.
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They used an intestinal tissue model and machine learning to identify interactions between drugs and transporters.
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The model predicted that the antibiotic doxycycline interacts with the blood thinner warfarin and other common drugs. Patient data confirmed this.
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The approach identified nearly 2 million potential drug interactions, including new ones not previously known.
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This technology could help improve drug absorption, prevent interactions, and tune new drugs under development.